In today’s world the boundaries between disciplines seem to be becoming increasingly blurred. Tools, once used only by professionals, are nowadays accessible to all, irrespective of their initial experience and knowledge. The question arises, what is the difference between science and design, where are their junctions and where are the conflicts between them? This text attempts to compare science and visual communication design through the analysis of process, methods and examples of design practice, where the areas met, intersected, or developed in parallel. The design profession, as a discipline at the crossroads of science, art and technology, has had, long before any official formal establishment, representatives, who were involved in changing things with visual communication tools. Historical examples as well as contemporary trends in this field enable us to conclude that science and visual communication design are not only related, but they can also mutually influence each other. Therefore the future offers great potential in the interdisciplinary collaboration between the two areas.